Fresh Cells from Mouse Hippocampus in Suspension, as Tissue and on MEA Plates.
Hippocampus
Hippocampus cultures have been dissected from the hippocampal formation. Preparation day is at embryonic day 18, E18. These cultures consist of approximately 20% neurons and 80% glial cells, mainly astrocytes and also 1% microglia 28 days after plating. These hippocampal preparations contain GABAergic and glutamatergic cells. Pharmacological studies show that these cells are sensitive to compounds targeting ionotropic and metabotropic receptors.
Quality Check
Cultures in suspension.
Cultures in suspension have high viability. Quotation of the number of cells refers to viable cells. Cells are checked to be free of Mycoplasma and Klebsiella.
Tissues
Tissues are viable and have more than 70% of viable cells. Each preparation is checked to be free of Mycoplasma and Klebsiella.
Pre-cultured MEA plates Pre-cultured microelectrode array plates will be tested for activity before shipping. Only plates with 80% active wells with each more than five active units will be shipped.
Disease modeling
Primary neuronal cell cultures from the Hippocampus are usable for in-vitro disease models. These disease models are very predictive because of their physiological relevance. The cell cultures comprise a wide variety of receptors and are essential tools to study long term potentiation, neurodegenerative diseases, such as Parkinson’s disease or Alzheimer’s disease. Read more Link: NeuroProof Disease Model, or neurological diseases as Epilepsy Link: NeuroProof Epilepsy.
Applications
Toxicity and Safety Pharmacology
Hippocampal cultures are useful tools for neurodevelopmental toxicity assays because they can be maintained in culture for a long time up to months.
They are valuable in viability and cytotoxic assays, read more.
Hippocampal cultures were also used for assays to predict a compound’s safety profile of seizurogenecity and sedation, read more. Seizurogenecity is an unwanted side effect of drugs and a cause of failed clinical trials. Compounds can provoke ictal events as seizures in the hippocampus, detectable with microelectrode arrays or C2+-imaging. Hippocampus cultures are sensitive to most hazardous compounds acting via the central nervous system.
Pharmacology
Hippocampus cortex cultures are sensitive to broad classes of drugs. They act via ionotropic or metabotropic receptors or other drug targets.
Hippocampus
Hippocampus cultures have been dissected from the hippocampal formation. Preparation day is at embryonic day 18, E18. These cultures consist of approximately 20% neurons and 80% glial cells, mainly astrocytes and also 1% microglia 28 days after plating. These hippocampal preparations contain GABAergic and glutamatergic cells. Pharmacological studies show that these cells are sensitive to compounds targeting ionotropic and metabotropic receptors.
Quality Check
Cultures in suspension.
Cultures in suspension have high viability. Quotation of the number of cells refers to viable cells. Cells are checked to be free of Mycoplasma and Klebsiella.
Tissues
Tissues are viable and have more than 70% of viable cells. Each preparation is checked to be free of Mycoplasma and Klebsiella.
Pre-cultured MEA plates Pre-cultured microelectrode array plates will be tested for activity before shipping. Only plates with 80% active wells with each more than five active units will be shipped.
Disease modeling
Primary neuronal cell cultures from the Hippocampus are usable for in-vitro disease models. These disease models are very predictive because of their physiological relevance. The cell cultures comprise a wide variety of receptors and are essential tools to study long term potentiation, neurodegenerative diseases, such as Parkinson’s disease or Alzheimer’s disease. Read more Link: NeuroProof Disease Model, or neurological diseases as Epilepsy Link: NeuroProof Epilepsy.
Applications
Toxicity and Safety Pharmacology
Hippocampal cultures are useful tools for neurodevelopmental toxicity assays because they can be maintained in culture for a long time up to months.
They are valuable in viability and cytotoxic assays, read more.
Hippocampal cultures were also used for assays to predict a compound’s safety profile of seizurogenecity and sedation, read more. Seizurogenecity is an unwanted side effect of drugs and a cause of failed clinical trials. Compounds can provoke ictal events as seizures in the hippocampus, detectable with microelectrode arrays or C2+-imaging. Hippocampus cultures are sensitive to most hazardous compounds acting via the central nervous system.
Pharmacology
Hippocampus cortex cultures are sensitive to broad classes of drugs. They act via ionotropic or metabotropic receptors or other drug targets.
Hippocampus 191101
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